胰岛素样生长因子-Ⅰ受体异常激活与肝癌靶向治疗

摘要

Abnormal activation of the insulin-like growth factor-Ⅰ receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis.IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target for HCC therapy.This review summarizes the recent research of the IGF-IR signaling pathway 's abnormal activation in HCC and the results of molecular targeting studies.%肝细胞恶性转化和癌变过程中,胰岛素样生长因子-Ⅰ受体(IGF-IR)异常活化.IGF-IR过表达既可作为肝癌早期诊断的标志,又可作为肝癌靶向治疗的新靶点,且具有应用前景.本文对IGF-IR信号通路异常激活及分子靶向治疗肝癌等的研究进展作了综述.