微小RNA(miRNA)是一类最新发现的短小内源性非编码RNA,其中miR-15家族生理状态下参与细胞凋亡、分化与周期调控、应激等重要细胞功能活动的调节,而在病理状态下与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关,具有潜在的治疗前景.本文就miR-15家族在肝癌、急性肝衰竭、肝纤维化和慢性肝病中的重要功能及治疗应用前景作一综述.%Since their recent discovery, microRNAs (miRNAs) , a class of short endogenous non - coding RNAs, have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes. Under normal physiological conditions, the miR - 15 family members regulate several important cellular functions, including apoptosis, cell differentiation, cell cycle, and stress responses. However, under pathological conditions, the miR -15 family members contribute to carcinogenesis, cardiovascular dysfunctions, and neurodegeneration; these activities may represent potentially useful targets of molecular therapeutic strategies. In this review, we summarize and discuss the important functions and promising therapeutic applications of the miR - 15 family in liver cancer, acute liver failure, liver fibrosis, and liver damage.
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