白细胞介素28B基因多态性与慢性HBV、HCV感染的相关性

摘要

Chronic infection with hepatitis B /C virus (HBV /HCV)is a widespread epidemic in China.The single nucleotide polymorphisms (SNPs)in interleukin 28B (IL28B)gene have been associated with chronic HBV /HCV infection and response to interferon therapy.The biological functions and characteristics of IL28B are elaborated on,the associations between HCV infection and IL28B SNPs are commented on,and current reports of associations between HBV infection and IL28B SNPs are reviewed.The results support the associations between IL28B SNPs and disease progression of HCV infection or the curative effect of interferon therapy.However,contradictive results have been obtained in studies of associations between IL28B SNPs and disease progression of HBV infection,the incidence of liver cirrhosis and primary liver cancer after HBV infection,or the curative effect of interferon therapy,so further investigation is needed.%HBV、HCV 感染具有慢性化的流行特点。白细胞介素（IL）28B 基因多态性与 HBV、HCV 感染慢性化及干扰素（IFN）抗病毒疗效具有相关性。简述了 IL -28B 生物学功能及特点，述评了 IL -28B 基因多态性与 HCV 感染的相关性，并归纳了目前发现的IL -28B 基因多态性与 HBV 感染的相关性的众多研究报道。分析表明，IL -28B 基因多态性与丙型肝炎病程转归及 IFN 抗病毒疗效的相关性研究报道较为一致；而 IL -28B 基因多态性与乙型肝炎病程转归，HBV 感染后肝硬化、肝癌及 IFN 抗病毒疗效的相关性研究，各方学者均有不同的见解，尚需进一步的研究。