T细胞免疫球蛋白黏蛋白分子3与HBV感染的研究进展

摘要

研究发现T细胞免疫球蛋白黏蛋白分子（TIM）3与许多疾病的发病相关联。HBV感染机体时，TIM-3作为一个负性免疫调节分子，在CD8＋T细胞上的表达明显增高，这表明它与HBV的发病机制密切相关。从TIM-3的生物学特性、HBV疾病转归和治疗靶点等方面回顾总结了TIM-3与HBV感染的最新研究进展，认为TIM-3将会成为HBV治疗的新靶点。%Studies have found that T cell Ig-and mucin-domain-containing molecule-3 (TIM-3)is associated with the development of many diseases.In hepatitis B virus (HBV)infection,TIM-3 acts as a negative immune regulatory molecule and its expression on CD8 +T cells increases markedly.It indicates that TIM-3 is closely related to the pathogenic mechanism of HBV infection.The latest research progress in TIM-3 and HBV infection,including the biological characteristics of TIM-3 and the outcomes and new therapeutic target of HBV infection,is reviewed and summarized.It is thought that TIM-3 will become a new target in the treatment of HBV.