肝特异性miR-122调控肝脏疾病的研究进展

摘要

miRNA-122（miR-122）是肝特异性微小RNA，在肝脏的生理功能和疾病方面都有重要的作用。阐述了miR-122与脂肪性肝炎的相关性及可能机制，探讨了miR-122表达水平的改变参与调控HCV和HBV感染的作用及机制，并归纳了miR-122在肝细胞癌（HCC）的发生发展中的作用。认为miR-122在肝脏中的诸多功能可为未来研发治疗肝脏疾病的药物提供新的靶点及新的治疗策略。%MicroRNA-122 (miR-122),a liver-specific microRNA,has important functions in the physiological function and disease development of the liver.The association of miR-122 with steatohepatitis and its possible action mechanism are described,and the effects of altered miR-122 expression in regulating infections with hepatitis B virus and hepatitis C virus are discussed.In addition,the roles of miR-122 in the development and progression of hepatocellular carcinoma are summarized.It is thought that the functions of miR-122 in the liver provide a new target and therapeutic strategy for treatment of liver diseases.