神经前体细胞表达下调蛋白9在胰腺癌组织中的表达及临床意义

摘要

Objective To investigate the expression of neural precursor cell -expressed,developmentally down -regulated 9 (NEDD9)in pancreatic cancer tissues and adjacent tissues and its association with the progression and prognosis of pancreatic cancer.Methods A total of 98 patients with pancreatic cancer who were treated in The Third People′s Hospital of Wuxi from August 2005 to December 2010 were en-rolled,and the samples of pancreatic cancer tissues and adjacent tissues were collected.Immunohistochemistry was used to measure the ex-pression of NEDD9 in pancreatic cancer tissues and adjacent tissues.The chi -square test was used for comparison of categorical data be-tween groups.Results The high expression rate of NEDD9 in pancreatic cancer tissues was significantly higher than that in adjacent tissues (57.1% vs 41.8%,χ2 =4.592,P =0.032).The expression of NEDD9 in pancreatic cancer tissues was significantly associated with TNM stage,degree of tumor differentiation,and lymph node metastasis (χ2 =45.02,20.41,and 36.21,all P <0.001)and not associated with sex,age,tumor location,or presence or absence of liver metastasis (all P >0.05).Conclusion NEDD9 may play a role in the progres-sion and invasion /metastasis of pancreatic cancer and can be used as a prognostic marker and a therapeutic target for pancreatic cancer.%目的：检测神经前体细胞表达下调蛋白（NEDD）9在胰腺癌和癌旁组织的表达情况，分析其与胰腺癌进展、预后的关系。方法收集2005年8月－2010年12月于无锡市第三人民医院治疗的98例胰腺癌患者的癌和癌旁组织样本，应用免疫组化技术检测患者胰腺癌和癌旁组织中 NEDD9的表达，并对 NEDD9表达与胰腺癌临床病理特征的关系进行分析。计数资料组间比较采用χ2检验。结果胰腺癌组织中 NEDD9的高表达率明显高于癌旁组织（57．1％ vs 41．8％，χ2＝4．592，P ＝0．032）。胰腺癌组织NEDD9的表达与患者 TNM分期、分化程度及有无淋巴结转移相关（χ2值分别为45．02、20．41、36．21，P 值均＜0．001）；与性别、年龄、肿瘤部位、有无肝转移无相关性（P 值均＞0．05）。结论 NEDD9可能在胰腺癌的发展和侵袭转移中起着一定的作用，有可能作为评估胰腺癌预后的分子指标和治疗靶点。