上消化道症状与幽门螺杆菌感染及胃癌前疾病的相关性研究

摘要

目的探讨上消化道症状与幽门螺杆菌（ Hp）感染及胃黏膜癌前病变的相关性。方法临床纳入2010年1月至2014年10月期间门诊初诊为慢性胃炎的患者，其中上消化道症状阳性组的患者360例，上消化道症状阴性组的患者360例，所有患者均通过碳14呼气试验进行Hp检测及胃镜下活检检测诊断，分别比较有无上消化道症状对患者的Hp阳性检出率之间的关系；以及有无上消化道症状与胃镜活检诊断为胃癌前疾病的相关度。结果上消化道症状阳性组Hp检出率高于上消化道症状阴性组（ P <0.05）；上消化道症状阳性组的慢性胃炎伴不典型增生组的发病率n　　明显高于上消化道症状阴性组，差异有统计学意义（ P <0.05）。结论上消化道症状与Hp感染具有相关性，上消化道症状与慢性胃炎伴不典型增生具有相关性。%Objective To investigate the relationship of upper gastrointestinal symptoms to Helicobacter pylori( Hp)infection and gastric precancerous lesions. Methods Chronic gastritis patients including 360 with upper gastrointestinal symptoms and 360 without upper gastrointesti-nal symptoms treated in our hospital between January 2010 and October 2014 were enrolled in the study. All patients received 14 C urea breath test and gastroscopic biopsy examinations. The relationship of gastrointestinal symptoms to Hp detection rate and gastric mucosa precancerous lesions was analyzed. Results Hp positive rate in patients with upper gastrointestinal symptoms was higher than patients without upper gastrointestinal tract symptoms( P <0. 05). The incidence of atypical hyperplasia was obviously higher in patients with upper gastrointestinal symptoms than pa-tients without upper gastrointestinal symptoms,the difference was statistically significant( P <0. 05). Conclusion The upper gastrointestinal symptoms are positively correlated with Hp infection and atypical hyperplasia in patients with chronic gastritis.