Objective To observe different doses of fluoride laval statin BNP in patients with senile coronary heart disease,heart failure and the influence of cardiac function. Methods From April 2013 to January 2014,96 cases of senile heart failure patients were retrospectively analyzed. All these cases can be divided into three groups,accepting fluorine laval statin 40 mg/ day(40 mg statin group 1)32 cases,fluorine la-val statin 80 mg/ day(80 mg statin group)34 cases and control group 30 cases of routine treatment. Respectively before treatment,medication, medication 6 months to 12 months after the detection of patients with BNP,6 minutes walk test,and left ventricular heart colour were used to ex-ceed testing scores,including left ventricular ejection fraction(LVEF),left ventricular diastolic diameter(LVEDD)final and hs - CRP levels. Results The effective accounting of 40 mg atorvastatin group and 80 mg atorvastatin group were significantly higher,the difference was statistically significant( P ﹤ 0. 05). And 40 mg atorvastatin group 1 and 80 mg atorvastatin group markedly effective accounting and no significant difference ( P ﹥ 0. 05);after treatment,the three groups of serum NT - proBNP,serum BNP,serum hs - CRP level and compared treatment LVEDD front lower,LVEF,6 min walking distance than before treatment increased( P ﹤ 0. 05),in which 80 mg atorvastatin group compared with the control group and 40 mg statin therapy more significant reduction in the group( P ﹤ 0. 05). Conclusion Elderly patients with coronary heart disease, heart failure in foundation treatment with cutting statins,the fluorine can significantly reduce the patients’serum BNP,hs - CRP level,increase the six minutes walking distance,improves cardiac function in patients,and 80 mg of fluorine cut statin efficacy is better than that of 40 mg of cutting statins,the fluorine is worth further promotion in the clinical practice.%目的：研究分析不同剂量的氟伐他汀对老年冠心病心衰患者脑钠肽（ BNP）及心功能的影响。方法从2013年4月到2014年1月，选取96例老年心衰患者进行回顾性分析，将其分为三组，接受氟伐他汀40 mg/ d（40 mg 他汀组）32例，氟伐他汀80 mg/ d（80 mg 他汀组）34例，对照组30例进行常规治疗。分别于治疗前、用药6个月、用药12个月后检测患者 BNP、N 末端心房利钠肽（NT - proBNP）、6 min 步行试验及心脏彩超测左室相关分数，包括左室射血分数（LVEF），左室舒张期末径（LVEDD）以及超敏 C 反应蛋白（hs - CRP）水平。结果40 mg 他汀组以及80 mg 他汀组显效和有效比率均显著高于对照组，差异均有统计学意义（均 P ﹤0.05）。而40 mg 他汀组1以及80 mg 他汀组显效和有效占比差异无统计学意义（ P ﹥0.05）；治疗后，三组血清 NT - proBNP、血清 BNP、血清 hs - CRP 水平以及 LVEDD 均较治疗前降低，LVEF、6 min 步行距离较治疗前增加（ P ﹤0.05），其中80 mg 他汀组较之对照组及40 mg 他汀治疗组降低幅度更明显（ P ﹤0.05）。结论老年冠心病心衰患者在基础治疗上加用氟伐他汀，能显著降低患者血清 BNP、hs - CRP水平，增加6 min 步行距离，改善患者心功能，且80 mg 氟伐他汀疗效优于40 mg 氟伐他汀，值得临床进一步推广。
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