Objective To explore the efficacy of ozagrel sodium combined with low molecular heparin calcium in treatment of patients with acute cerebral infarction and its influence on their status of pre-thrombotic condition and prognosis. Methods A total of 100 patients with acute cerebral infarction were divided into observation group and control group according to random number table method,patients in these two groups were given with conventional treatment,patients in control group were additionally given with enteric-coated aspirin,and patients in observation group were additionally given with sodium ozagrel and low molecular heparin calcium. Activated part clotting time (APTT),platelet count (PLT),thrombin time (TT),prothrombin time (PT)and fibrinogen (FIB)were examined and recorded before and after treatment. The levels of 6-ketone-prostaglandin F1 alpha (6-K-PGF1 alpha),thromboxane B2 (TXB2),the detection of serum platelet membrane protein (GMP140)alpha particles and false von Willebrand factor (vWF)were determined. The determination of thickness of the wall of carotid artery -(IMT). Nerve function scores and efficiency of treatment were recorded. Results After treatment,the level of FIB in observation group was lower than that of control group. The levels of 6-K-PGF1 alpha,plasma TXB2,serum GMP140 and vWF levels and carotid IMT in patients of ob-servation group were superior to those of patients in control group. The nerve function defect scores in observation group were lower than those of control group. The efficiency in observation group was higher than that of control group. All of them had significant difference (P < 0. 05). Con-clusion The efficacy of application of ozagrel sodium combined with low molecular heparin calcium in treatment of patients with acute cerebral in-farction is significant,it can improve the function of blood coagulation in these patients,inhibit the aggregation of platelets,increase the blood sup-ply of brain,improve the status before thrombosis and alleviate the nerve defect,hence it has certain effect on the improvement of prognosis of these patients.%目的 分析急性脑梗死患者采用奥扎格雷钠联合低分子肝素钙治疗对血栓前状态及预后的影响.方法 纳入符合本研究各项标准的急性脑梗死患者100例,随机数字表法为两组,均行常规治疗,对照组加阿司匹林肠溶片;观察组在对照组基础上加奥扎格雷钠和低分子肝素钙.记录治疗前后活化部分凝血活酶时间(APTT)、血小板计数(PLT)、凝血酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB);检测血浆6-酮-前列腺素F1α(6-K-PGF1α)、血栓素B2(TXB2)水平,检测血清血小板α颗粒膜蛋白(GMP140)、血管性假血友病因子(vWF)水平,测定颈动脉内-中膜厚度(IMT).记录神经功能评分和治疗有效率.结果 治疗后观察组FIB降低且低于对照组;观察组血浆6-K-PGF1α、TXB2水平,血清GMP140、vWF水平及颈IMT均优于对照组;观察组神经功能缺损评分降低且低于对照组;观察组治疗有效率高于对照组,差异均有显著性(P<0.05).结论 奥扎格雷钠联合低分子肝素钙治疗急性脑梗死疗效显著,能改善患者纤维蛋白原水平,抑制血小板聚集,增加脑供血,改善血栓前状态,缓解神经缺损,对预后的改善有一定作用.
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