病态窦房结综合征患者血清甲状腺激素水平的变化

摘要

目的 探讨病态窦房结综合征(SSS)患者血清中甲状腺激素水平的变化及临床意义.方法 回顾性分析336例SSS患者(SSS组),102例因其它疾病住院的非SSS患者(对照组).比较两组血清甲状腺激素水平;SSS合并心房颤动组与不合并心房颤动组之间甲状腺激素水平;SSS合并房室传导阻滞组与不合并房室传导阻滞组之间甲状腺激素水平.结果 SSS组血清TT3、FT3水平明显低于对照组(P0.05).SSS患者合并房颤组和不合并房颤组之间、合并II度以上房室传导阻滞组和不合并II度以上房室传导阻滞组之间TT3、TT4、FT3、FT4、TSH水平均无显著性差异(P>0.05).结论 正常范围内低甲状腺激素水平可引起窦房结功能减退.%Objective To explore the clinical significance and changes in serum levels of thyroid hormones in patients with sick sinus syndrome (SSS).Methods The data of serum level of thyroid hormones in 336 patients with sick sinus syndrome (SSS group) and 102 patients with other diseases without SSS in this hospital (control group) were retrospectively ananlyzed.The serum levels of thyroid hormones (FT3, FT4 and TSH) were compared between SSS group and non-SSS group, SSS with atrial fibrillation (AF) group and SSS without AF group, SSS with II degree or above atrioventricular block (AVB) group and SSS without AVB group.Results The serum levels of TT3 and FT3 in patients with SSS group were significantly lower than those of patients with non-SSS group (P0.05).However, serum levels of TT3, TT4, FT3, FT4 and TSH were not significantly different between AF group and non-AF group, II degree or above AVB group and non-II degree AVB or above group (P>0.05).Conclusion Low serum levels of thyroid hormones within normal range can cause the dysfunction of sinus.