Objective To study influence of epidural anesthesia for labor analgesia on maternal serum IL-6, NO and T cell subsets.Methods 90 puerperants from June 2014 to July 2015 in our hospital were researched.They were divided randomly into observation and control groups.45 patients in the observation group, they were treated by CSEA labor analgesia.45 patients in the control group, using natural childbirth.The efficacy, IL-6, NO concentration change, T cell subsets levels, adverse reactions were compared.Results In parturition, total effective rate of the observation group (91.11%) higher than the control group (75.56%), there were significant differences (P0.05).The levels of IL-6 and NO in the two groups were higher than those in the control group at 24 h after delivery, and the levels of IL-6 and NO in the observation group were significantly lower than those in the control group (P0.05).24 hours after parturition, the level of CD4+, CD4+/CD8+ of the observation group decreased faster than the control group, the level of CD8+ of the control group decreased faster than the observation group, and there were significant differences (P0.05);分娩后24 h,两组产妇IL-6及NO浓度均有升高,且观察组产妇IL-6及NO浓度低于对照组,差异有统计学意义(P0.05);分娩后24 h,观察组产妇的CD4+及CD4+/CD8+水平下降幅度小于对照组,观察组产妇CD8+水平下降幅度大于对照组,差异有统计学意义(P<0.05).分娩后,观察组不良反应总发生率(11.11%)低于对照组(51.11%),差异有统计学意义(P<0.05).结论 腰硬联合麻醉对产妇分娩镇痛疗效显著,可降低产妇IL-6及NO浓度,降低CD4+、CD8+、CD4+/CD8+水平,减少不良反应发生,安全性较高.
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