激素表达与乳腺癌HER-2表达之间的年龄相关性研究

摘要

Objective To investigate whether the relationship between the expression of hormone receptors and HER-2 in different age range. Methods A total of 259 cases of invasive breast cancer were collected. The expression of estrogen receptor( ER),progesterone receptor (PR),human epidermal growth factor receptor2(HER-2)were detected by immunohistochemistry(IHC). Fluorescence in situ hybridization ( FISH)was applied to determine the HER-2 gene status in cases scored IHC 2+. The patients were divided into four groups and the relationship between the expression of ER,PR and HER-2 was analyzed in each groups. Results In the group with 41~50 years old,the positive rate of HER-2 was 50. 0% in ER( -)group while it was 15. 8% in ER( +)group. The difference was significant. The positive rate of HER-2 was 51. 9% in PR( -)group while it was 11. 5% in PR( +)group. The difference was significant. In the group with 51~60 years old,the positive rate of HER-2 was 50. 0% in ER( -)group while it was 17. 9% in ER( +)group. The difference was significant. The positive rate of HER-2 was 45. 7% in PR( -)group while it was 10. 0% in PR( +)group. The difference was also significant. There was no negative correlation in the other groups. The positive rate of ER、PR expression in the group aged ﹥60 years old was significantly higher than that in the other two groups. Conclusion The association between the expression of hormone receptors and HER-2 is age-related. This negative correlation is just applied to the patients aged 41~60 years.%目的：探讨激素表达与乳腺癌人类表皮生长因子受体-2（ HER-2）的表达之间是否具有年龄相关性。方法收集浸润性乳腺癌259例，免疫组化方法检测雌激素（ ER）、孕激素（ PR）、HER-2的表达；对于HER-2为2+的病例，进一步应用FISH法检测HER-2基因的扩增；根据年龄将病人分为4组，分析ER、PR的表达与HER-2的表达的年龄相关性。结果年龄41~50岁组中，ER（-）组中HER-2的阳性率为50.0％，高于ER（+）组HER-2的阳性率15.8％，两者之间差异有统计学意义（ P ﹤0.05）；PR（-）组中HER-2的阳性率为51.9％，高于PR（+）组HER-2的阳性率为11.5％，两者之间差异有统计学意义（ P ﹤0.05）；年龄51~60岁组中，ER（-）组中HER-2的阳性率为50.0％，高于ER（+）组HER-2的阳性率17.9％，两者之间差异有统计学意义（ P ﹤0.05）；PR（-）组中HER-2的阳性率为45.7％，高于PR（+）组HER-2的阳性率10.0％，两者之间差异有统计学意义（ P ﹤0.05）；其他年龄分组中不存在这种相关性。﹥60岁年龄组中，ER和PR的阳性率明显高于其他两组（ P ﹤0.05）。结论 ER、PR的表达与HER-2的表达具有年龄相关性，这种负相关性只适用于41~60岁的乳腺癌病人。