非小细胞肺癌术后免疫功能与铁蛋白、癌胚抗原的相关性

摘要

目的 观察非小细胞肺癌术后免疫功能与血清铁蛋白(SF)、癌胚抗原(CEA)的相关性.方法 回顾性纳入2016年1月至2018年1月收治的90例经手术治疗的非小细胞肺癌为对象.统计患者一般资料、病理学资料,于术后3～4周抽取患者清晨空腹外周静脉血5 ml,采用电化学发光免疫法检测SF、CEA.参照各试剂盒,明确SF与CEA阳性界值,分为四组,即SF阳性组(SF≥336.2 ng/ml,31例)、SF阴性组(SF0.05),SF水平及CD3+、CD8+百分比显著低于SF阳性组(P0.05),CEA、SF水平及CD8+百分比显著低于CEA阳性组(P 0. 05). SF level and CD3 + and CD8 + percentages were significantly lower than those in SF positive group (P 0. 05),CEA,SF level and the percentage of CD8 + was significantly lower than that in CEA positive group (P < 0. 05),NK, CD4 + cell percentage and CD4 + / CD8 + ratio was significantly higher in CEA positive group (P < 0. 05). In 90 cases of non - small cell lung cancer patients,the postoperative level of CEA and NK cells,T cell subsets (CD4 +,CD8 + and CD4 + / CD8 + ratioo)were correlated (P <0. 05),the postoperative level of SF and NK cells,T cell subsets (CD3 +,CD4 +,CD8 + ％ and CD4 + / CD8 + ratio)was related (P < 0. 05). Conclusion The status of immune dysfunction in patients with non - small cell lung cancer is related to the level of SF and CEA,which should be paid more attention in clinical practice.