三七根总皂甙对SMAO休克家兔肝脏的保护作用

摘要

Objective:To study the effects of panax pseudo-ginseng on the liver in rabbits suffered from SMAO shock.Methods:20 rabbits were divided randomly into control group and treatment group. SMAO (superior mesenteric artery occlusion)shock model was made by occluding the superior mesenteric artery for 1 hour. In treatment group, 200 mg/kg of panax pseudo-ginseng diluted in normal saline was given intravenously. In control group, the same volume of normal saline without drug was given intravenously. Mean blood pressures and 4-hour survival rates were monitored during the study. Biopsies from the left lobe of the liver were taken from all animals at the end of the study for microstructure study using electro-microscope.Results:Compared to control group, animals in the treatment group had a significant prolonged survival time and improved mean blood pressures. Impairment of hepatocytes in treatment group was significantly reduced. Conclusion: Panax pseudo-ginseng has benefit effects on the liver. This plays an important role in prolonging the survival time of the rabbits with SMAO shock.%目的：观察三七皂甙治疗后对休克兔肝脏超微结构的保护作用。方法：家兔20只，随机等分为对照组与治疗组。钳夹肠系膜上动脉制成SMAO休克模型。治疗组静注三七根总皂甙200mg/kg，对照组静注等量生理盐水。结果：治疗组存活时间明显延长，并改善MAP。休克期间肝细胞的破坏明显减轻，与对照组比较肝窦内枯否氏细胞功能较为活跃。结论：三七皂甙对肝脏有保护作用，对延长SMAO休克兔的存活时间起到了重要作用。