Objective To investigate the effect of anesthesia induction with high concentration of sevoflurane on the velocity of cerebral blood flow. Methods Twenty-four ASA physical status I -II patients (35-55 yr) scheduled for elective discectomy for lumbar intervertebral disc herniation were randomly assigned to two groups: group S was induced by inhalation with 8% sevoflurane; group P was induced with target-controlled infusion of propofol and remifentanil (target concentration: 2. 0-3. 0 μg/ml and 5.0-6.0 ng/ml, respectively). Blood flow velocity in the middle cerebral artery (Vmca) was measured using transcranial Doppler ultrasonography. Mean Vmca (Vmean), MAP and HR were recorded before induction (T0), 1 min (T1), 2 min (T2) and 3 min (T3) after inductioa Results Vmean in group S at T1 increased significantly compared with the baseline in group S and that of group P at T1 (P<0. 05). Vmean in group P had no significant differences between various time points. Conclusion Anesthesia induction with 8% sevoflurane can accelerate the velocity of cerebral blood flow.%观察吸人高浓度七氟醚(8％)诱导时大脑中动脉血流速度的变化.方法 椎间盘突出择期行髓核摘除的患者24例,年龄35～55岁,ASA Ⅰ或Ⅱ级,依诱导方式的不同随机均分为两组,8％七氟醚吸入组(S组)和靶控输注(TCI)丙泊酚-瑞芬太尼组(P组).记录诱导前(T0)、诱导后l min (T1)、2min(T2)、3min (T3)时的脑血流平均速度(Vmean)、MAP及HR.结果 T1时S组Vmean明显快于T0时及P组(P＜0.05),P组各时点Vmean变化差异无统计学意义.结论8％七氟醚吸入诱导可使脑血流速度加快,尤以诱导后1 min最明显.
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