Objective To evaluate the effect of ketamine or ketamine combined with dexmedetomidine in dressings changing in pediatric burn patients. Methods Twenty pediatric burned patients undergoing dressings changing were allocated to receive ketamine plus dexmedetomidine (group A, dexmedetomidine 6 μg ·kg-1 -h-1 and ketamine 1 mg/kg 10 min after the beginning of dexmedetomidine) or ketamine (group B, ketamine 1 mg/kg). Additional 0. 5 mg/kg ketamine was injected under inadequate anesthesia. During the procedure, MAP, HR, RR, Pet CO2 , SpO2 and Ramsay scale were recorded at baseline (T1 ) , 10 min after infusion(T2 ) , lmin(T3 ) , 5min(T4 ) , 10 min(T5) after dressings changing, and at the end changing (T6 ). The operation time, ketamine consumption and eyes-open time were recorded pediatric anesthesia emergence delirium (PAED) and postoperative nausea and vomiting were observed in PACU. We also compared satisfaction of the surgeons and the parents. Results At T2-T6, the hemodynamics in group A was more stable than that of group B(P<0. 05). Ramsay scale in group A was lower than that in group B at T2 (P展开▼
