Objective To evaluate the value of the fusion of 99m Tc-MIBI imaging technology apply in the diagnosis of malignant lung tumor. Methods Thirty - four cases with lung nodules proved by X-ray and/or CT scanning, a total of 48 lung nodular lesions. And the imaging with-99m Tc-MIBI of chest performed at 10 minutes and 2 hours delayed after injection by GE Infinia Hawkeye 4 SPECT-CT. then the regions of interesting ( ROI) were drawn in the tumor and contra lateral position to calculate the radioactivity ratios of tumor to normal ( T/NT) , and fused with the spiral CT scanning image in the same machine, and reading the early and delayed image respectively. Judged the result of the image develops, and statistical analysis of the ratio (T/NT) according to the final pathologic consequence. Results All cases with total of 48 nodular lesions, 21 nodules were positive in early imaging, 16 nodules were positive in delayed imaging (the ratio T/NT over 3. 33). defined the delayed image positive as the final criterion, The(T/NT)ratios of Malignant lung lesions were significantly higher than the benign lesions ( P ＜0. 05). Negative nodes 27, 13 cases of lung cancer lesions were malignant, confirmed by postoperative pathologic examination. The falsepositive nodules 3, false-negative nodules 2. The sensitivity was: 88.88%, the specificity was: 90.9% positive predictive value ( +PV) was: 84. 21% , negative predictive value (-PV) is: 93.75%. Conclusion 99mTc-MIBI as a tumor positive imaging agent is highly sensitivity to lung lesions, but specificity is not so high.%目的 评价同机图像融合技术99mTc-MIBI显像对肺部恶性肿瘤的诊断价值.方法 临床经X线平片或CT扫描发现肺部结节患者34例,共计48个肺部结节样病灶,以GE公司InfiniaHawkeye 4 SPECT-CT行10min及2h延迟胸部断层99mTc-MIBI显像,以ROI技术测定其T/NT比值,并以同机螺旋CT扫描同机图像融合,对早期及延迟图像分别读片,判断显影结果,并对其T/NT比值根据其最终病理结果进行统计分析.结果 34例患者共计48个肺部结节,早期显像阳性结节数21,延迟显像阳性结节数16,(T/NT比值＞3.33),以延迟显像阳性为最终判定标准,肺部恶性病灶其T/NT比值较良性病灶差异有统计学意义(P＜0.05).阴性结节数为27,经手术病检证实13例为肺部恶性肿瘤病灶,假阳性结节数3,假阴性结节数为2,其灵敏度88.88%,特异性90.9%,阳性预测值+PV 84.21%,阴性预测值-PV 93.75%.结论 99mTc-MIBI作为一种肿瘤阳性显像剂,对于肺部占位性病变的灵敏度高,但其特异性不高,而99mTc-MIBI显像和CT扫描,其可提高其诊断价值,与普通SPECT显像相比,灵敏度及特异性均有显著提高.可在不具备PET-CT及符合探测SPECT设备的基层医院及经济欠发达地区运用.
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