sTREM-1在AECOPD患者治疗及疗效评估中的临床价值研究

摘要

Objective To investigate the clinical value of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the treatment and therapeutic effect evaluation of patients with an exacerbation of chronic obstructive pulmonary disease.Methods The levels of serum sTREM-1,procalcitonin (PCT) and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA) in 49 exacerbation of chronic obstructive pulmonary disease (COPD) subjects [acute exacerbation of chronic obstructive pulmonary disease (AECOPD) group],49 stable COPD subjects(sCOPD group) after treatment and 49 healthy volunteers as healthy control group.The levels of sTREM-1,PCT and CRP in different groups were compared and the relationship between the level of sTREM-1 in AECOPD and sCOPD groups,and PCT,and CRP was analyzed,respectively.Results The content of sTREM-1,PCT and CRP between different groups had significant difference(P ＜0.05).The level of sTREM-1 in both AECOPD and sCOPD groups was significantly positive correlated with PCT (P ＜ 0.05) and negative correlated with CRP (P ＞ 0.05).Conclusions For guiding the treatment and curative effect evaluation of patients with AECOPD,sTREM-1 has important clinical reference value.%目的 探讨可溶性髓样细胞触发受体-1(sTREM-1)在指导慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗及疗效评估中的价值.方法 选择49例AECOPD患者,在急性加重期(AECOPD组)及在治疗达恢复期(sCOPD组)后测定其血清sTREM-1、降钙素原(PCT)、C反应蛋白(CRP),两组作自身对照,以健康者49例作为健康对照组,测定其上述炎性指标,比较不同组之间sTREM-1的差异,分析AECOPD组及sCOPD组各组血清sTREM-1与PCT、CRP的相关性.结果 (1)不同组间sTREM-1 、PCT、CRP水平差异有统计学意义(P＜0.05).(2) AECOPD组及sCOPD组血清sTREM-1水平与PCT均呈正相关(P＜0.05),与CRP均无明显相关(P＞0.05).结论 血清sTREM-1水平对指导AECOPD患者的治疗及疗效评估具有重要的临床参考价值.