趋化因子CXCL12及其受体CXCR4在喉咽癌的表达及意义的研究

摘要

目的 探讨趋化因子12 (CXCL12)和趋化因子受体4(CXCR4)在喉咽癌中的表达及其在该病发生、发展、浸润和转移中的临床意义.方法 采用免疫组织化学方法检测35例喉咽癌组织(观察组)及28例手术切除的癌旁非肿瘤组织(对照组)中CXCL12和CXCR4的表达.结果 CX-CL12和CXCR4在喉咽癌组织中的表达均明显高于对照组,差异均有统计学意义(P＜0.05).且两者在喉咽癌中的表达呈正相关(P＜0.01).两者在喉咽癌有颈淋巴结转移组中表达均明显高于无颈淋巴结转移组,其差异均有统计学意义(P＜0.05).结论 CXCL12和CXCR4均参与喉咽癌发生、发展、浸润和转移过程,并且二者之间存在正反馈调节机制,在喉咽癌的发生、发展、浸润和转移过程中起协同作用.%Objective To investigate the chemokine 12 (CXCL12) and chemokine receptor 4 (CXCR4) expressions in hypopharyngeal carcinoma and its place in the disease development,invasion and metastasis of significance.Methods Immunohistochemistry was used to detect the expressions of CXCL12 and CXCR4 in 35 cases of hypopharyngeal cancer tissues and in 28 cases of tumor-adjacent non-tumor tissues.Results The expressions of CXCL12 and CXCR4 in the hypopharynx carcinomas were significantly higher (P ＜ 0.05).Both expressed in hypopharyngeal carcinomas was significantly positively correlated (P ＜ 0.01).Both hypopharynx cancer in lymph node metastasis group were significantly higher than the expression of cervical lymph node metastasis group,the difference was significant (P ＜ 0.05).Conclusions CXCL12 and CXCR4 are involved in hypopharynx cancer development,invasion and metastasis,and there is a positive feedback regulation mechanism between two factors.Moreover,CXCL12 and CXCR4 have synergistic effect in development,invasion and metastasis of hypopharynx cancers.