海藻酸钠凝胶筏的研究进展

摘要

嘉胃斯康是典型治疗胃食管返流病的海藻酸钠制剂.它在胃酸中可以形成一种漂浮的凝胶筏,较好地阻止胃食管返流.我们评价这个体系的指标有多种参数,如强度、体积、漂浮性、耐受力和弹性.另外,凝胶筏的强度还受许多因素影响,如分子量、M/G的比值.这两种参数是影响筏强度大小的内在因素.一些外在的因素如筏中钙离子的存在,包裹在筏中的二氧化碳数量.本文主要总结了如何评价凝胶筏,介绍了影响凝胶筏的因素,最后概括了海藻酸钠的降解情况及未来的进展.%Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease (GERD) symptoms.Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents.This system can be characterized by several indicators,such as strength or coherence,volume,buoyancy,reflux resistance and resilience.In addition,the strength of the raft is influenced by many factors,such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues (M/G),which are intrinsic factors in this formulation.Besides,there are several extrinsic factors,such as the presence of specific cations,the amount of carbon dioxide generated and entrapped in the raft.This review focused on how to evaluate the raft,introduced some factors that impact the raft and summarized the degradation of alginate and future advance.