高强度聚焦超声壳式辐照离体牛肝组织的实验研究

摘要

Objective To investigate the efficiency of peripheral irradiating on ablation ox-liver tissue using high intensity focused ultra-sound (HIFU). Methods A Total of 30 cases of ox-liver tissues were randomly divided into 2 groups: the peripheral irradiation group re-ceived peripheral irradiation in region-of-interest but not in central zone;the traditional irradiation group was irradiated completely from deep area to superficial area. Results There was no significant difference of the volume of coagulation necrosis between the two groups (P > 0.05), while the exposure time,energy and energy efficiency factor (EEF) of the peripheral irradiation group were less than the traditional ir-radiation group (P < 0.05 ). Conclusion The coagulation necrosis of peripheral irradiation was the same as the traditional irradiation,while the exposure time and energy of were significantly reduced. The peripheral irradiation was more efficient than the traditional irradiation on HI-FU ablation.%目的 探讨高强度聚焦超声(HIFU)壳式辐照离体牛肝组织的辐照效率.方法 取30例离体牛肝组织,随机分为2组进行HIFU辐照:壳式辐照组,对感兴趣区的周边进行全封闭式辐照,而中心区域不投放能量；传统式辐照组,对感兴趣区逐层完全覆盖式辐照.结果 2组比较凝固性坏死体积无明显差异(P＞0.05),而壳式辐照组的辐照时间、投放的能量和能效因子均小于传统式辐照组(P＜0.05).结论 HIFU壳式辐照与传统式辐照产生的凝固性坏死体积相当,但辐照时间和投放的能量都减少,辐照效率较传统辐照方式更高.