高强度聚焦超声壳式辐照的不同线间隔时间对离体牛肝组织的影响

摘要

Objective To investigate the impacts of high intensity focused ultrasound (HIFU) peripheral scanning with different doublet interval time on irradiation of in vitro ox-liver tissue. Methods Totally 60 pieces of ox-liver tissues were randomly divided into 6 groups (2, 4, 6, 8, 10, 12 min) according to doublet interval time. Each group was irradiated on the periphery of same ROI with same dose using HIFU, Results Each group had formed integrated confinement of lesion. The tissue outside of ROI of 2 min group and 4 min group presented coagulation necrosis, when the other groups did not. Among 6 groups, the volume of the lesion decreased, while energy efficiency factor (EEF) increased and the efficiency of irradiation decreased in sequence. Conclusion With the doublet interval time decreases, the volume of the lesion increases, while EEF decreased and the efficiency of irradiation increases. The best doublet interval time of HIFU peripheral scanning on irradiation of in vitro ox-liver tissue is 6 min.%目的 探讨不同线间隔时间对高强度聚焦超声(HIFU)壳式辐照离体牛肝组织的影响.方法 根据线间隔时间将60个牛肝随机分为6组:2 min组、4 min组、6 min组、8 min组、10 min组、12 min组,每组用相同辐照剂量进行HI-FU壳式辐照同样大小的ROI的周边,对ROI内部区域不进行辐照.结果 每组辐照区均形成完整封闭的凝固性坏死带.各组凝固性坏死体积依次缩小,能效因子依次增大,辐照效率依次降低.除2 min组和4 min组外,其余各组未见明显ROI外周组织损伤.结论 随着线间隔时间缩短,坏死体积增大,能效因子减小,辐照效率增高；6 min是HIFU壳式辐照离体牛肝组织的最佳线间隔时间.