还原响应性两亲性梳型聚合物的合成及表征

摘要

As an initiator with alkoxyamino polyethylene glycol, we trigger the ring opening polymerization forγ-propargyl -L- carboxy glutamic -N- within anhydride (PLG-NCA) to obtain amphiphilic block copolymer. Based on these steps,we use click method to synthesize disulfide-labeled stimuli-responsive degradation comb-like block copoly-mer. At last, the generated polymer generates degradable and amphipathic micelles with sensitivity by self-assemble. These micelles with sensitivity are used to package,transport and release the cancer drugs. These micelles also have a higher stability and a better drug release. The experiment adopts doxorubicin hydrochloride as the wrapping drug by self-assemble in the solution of PBS of 1/15mol Ph=7.4.%以端氨基功能化的聚乙二醇单甲醚为引发剂，引发γ-炔丙基-L-谷氨酸-N-羧基内酸酐（PLG-NCA）开环聚合反应，获得聚氨基酸聚乙二醇两亲性嵌段共聚物。并以此为基础，用click方法合成带有二硫键标记的还原敏感性的可降解两亲性梳型嵌段聚合物。最后所得的这种聚合物在水溶液中自主装形成可降解的两亲性的敏感性胶束。这种带有敏感性的胶束可以用于抗癌药物的包覆以及运输和适时的释放；这种胶束具有更高的稳定性和更高的药物释放性。实验采用盐酸阿霉素作为包裹药物，在1/15mol pH=7.4的PBS溶液中进行自主装包裹药物。