目的：探讨银杏叶黄酮联合奥扎格雷钠对急性脑梗死患者血清 HIF-1α、TNF-α及 Caspase-3水平的影响及其意义。方法选取急性脑梗死的患者180例，随机分为2组，各90例，对照组行常规疗法治疗，实验组在对照组治疗基础上加用银杏叶黄酮注射液，检测2组临床疗效、神经功能缺损评分及血清 HIF-1α、TNF-α、Caspase-3水平，进而对2种疗法进行对比分析。结果实验组总有效率78.9℅，明显优于对照组的56.7℅（P ﹤0.05）；神经功能缺损评分明显低于对照组（P ﹤0.05）；血清 HIF-1α、Caspase-3、TNF-α水平低于对照组（P ﹤0.05）。结论银杏叶黄酮治疗急性脑梗死，能有效改善神经功能缺损评分，明显改善临床症状。%Objective To investigate the ginkgo biloba flavonoids combined with ozagrel in acute cerebral infarc-tion patients of serumHIF-1α,TNF-α and Caspase-3. Methods The 180 acute cerebral infarction patients were se-lected and divided into control group treated by clinical routine therapy and experiment group treated by ginkgo biloba flavone injection,the clinical efficacy of the two groups of patients,neurological impairment score and serumHIF-1α, TNF-α and Caspase-3 level. The clinical effect were compared by SPSS 17. 0. Results Compared with control group, the efficiency were higher(P ﹤ 0. 05). Compared with control group,the neurologic impairment score were lower(P ﹤0. 05). Compared with control group,the serum HIF-1α,TNF-α and Caspase-3 level were lower(P ﹤ 0. 05). Conclu-sion Flavonoids from the leaves of Ginkgo biloba on acute cerebral infarction patients better clinical curative effect, and can effectively improve symptoms in patients with neurological deficit,for the clinical treatment of cerebral infarc-tion with important significance.
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