抑郁症认知易感者脑灰质密度的基于体素的形态测量学分析

摘要

目的:探讨抑郁症认知易感者脑灰质密度的特征.方法:运用磁共振成像(MRI)技术采集30例抑郁症认知易感者及30例正常对照者的全脑解剖成像数据,应用基于体素的形态测量(voxel-based morphometry,VBM)方法分析比较两组研究对象全脑灰质密度的差异.结果:抑郁症认知易感者双侧脑岛、左侧小脑、右侧辅助运动区及左侧中央前回的灰质密度显著低于正常组(P＜0.001),而右侧额下回、右侧额中回及左侧楔叶的灰质密度显著高于正常组(P＜0.001).结论:抑郁症认知易感者存在脑灰质密度的异常,这可能是抑郁认知易感性的神经生物学机制之一.%Objective:To explore the grey matter concentration in individuals with cognitive vulnerability to depression.Methods:Thirty individuals with cognitive vulnerability to depression and thirty age-and gender-matched healthy controls were enrolled in this study,and they were subjected to magnetic resonance imaging (MRI) examination.The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI.Results:Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular,left cerebellum,right supplementary motor area,and left precentral gyrus than those in the healthy controls,while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus,right middle frontal gyrus,and left cuneus than those in the individuals with cognitive vulnerability to depression.Conclusion:Structural brain abnormalities in individuals with cognitive vulnerability to depression might be the neural basis for cognitive vulnerability to depression.