目的 研究β-环糊精和2,3,6-三甲氧基-β-环糊精对手性药物苯环壬酯的立体选择性识别作用.方法 分别将苯环壬酯与两种β-环糊精等体积混合形成包合物后直接进样,采用串联四级杆质谱法,在正离子检测方式下,分析其相对丰度,观察结合性,分析两种环糊精对手性分子苯环壬酯的立体识别能力.结果 β-环糊精对苯环壬酯的手性识别作用不明显；2,3,6-三甲氧基-β-环糊精对苯环壬酯对映异构体具有很强的立体识别能力.结论 2,3,6-三甲氧基-β-环糊精与苯环壬酯之间具有显著的立体选择性相互作用.%Objective To investigate the stereoselectivity recognition of p-cyclodextrin or 2,3 ,6-tri-o-methyl-fS-cyclodextrin as the chiral selector with phencynonate, a novel chiral anticholinergic agent. Methods (3-Cyclodextrin or 2, 3 , 6-tri-o-methyl-p-cyclodextrin was mixed with phencynonate in equal volume and formed the complexes, respectively. The samples were injected directly to the tandem quadrupole mass spectrometry. In positive ion mode, the relative abundances and the combination rate of p-cyclodextrin or 2, 3, 6-tri-o methyl-p-cyclodextrin with phencynonate isomer complex were analyzed. Results 2,3, 6-Tri-o-methyl-p-cyclodextrin had strong recognition ability of stereoselectivity to chiral phencynonate isomers, but the chiral recognition ability of p-cyclodextrin to phencynonate isomers was not significant. Conclusion There is markedly stereoselective interaction between 2,3, 6-tri-o-methyl-p-cyclodextrin and phencynonate.
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