衰弱与认知损害相关性研究进展

摘要

随着人口结构的快速转变和老年人口比例的增加,我国失能老年人的数量不断增多,照料这些失能的老年人将给社会带来沉重的医疗和经济负担.衰弱与认知损害是导致老年人失能最常见的原因.目前研究已经证实,衰弱与认知损害存在相互作用,衰弱的老年人更易发生认知损害,认知损害反过来加速衰弱的进展.因此,本文通过复习国内外新的相关文献,对衰弱、认知损害及其相互联系的潜在机制做一综述.%Rapid demographic changes with increasing percentage of old age,particularly in our country,will lead to larger number of elderly being at risk of dependent.Moreover,larger economical and medical burden will be brought for caring more and more dependent older people.Two of the most common causes of dependent are frailty and cognitive impairment.A number of studies have showed that frailty increases the risk of future cognitive decline and that cognitive impairment increases the risk of frailty.It is suggested that cognition and frailty interacted within a vicious cycle associated with ageing.This article reviews frailty,cognitive impairment,and the association between frailty and cognitive impairment.Some of the mechanisms that potentially underlying this relationship is discussed as well.