脑卒中患者早期血清BDNF、Hs-CRP及IGF-1含量与脑卒中后抑郁的关系探讨

摘要

目的 探讨脑卒中患者早期血清脑源性神经营养因子 (BDNF) 、超敏-C反应蛋白 (Hs-CRP及人胰岛素样生长因子-1 (IGF-1) 含量与脑卒中后抑郁的关系.方法 收集唐山市开滦总医院2016年3月至2018年2月收治的100例脑卒中患者为研究对象, 根据患者是否发生抑郁分为脑卒中后抑郁组 (观察组) 和脑卒中后非抑郁组 (对照组) , 观察组43例, 对照组57例.检测患者入院后第2天BDNF、Hs-CRP及IGF-1水平, 比较两组患者美国国立卫生研究卒中量表 (NIHSS) 评分、活动能力量表 (ADL) 评分及改良Rankin量表 (mRS) 评分并评估BDNF、Hs-CRP及IGF-1水平和抑郁的相关性.结果 和对照组相比, 观察组患者BDNF水平更低 (P<0.05) , Hs-CRP及IGF-1的水平更高 (P<0.05) , NIHSS及mRS评分更高 (P<0.05) ;ADL评分更低, 差异有统计学意义 (P<0.05) .Hs-CRP水平与抑郁评分呈现正相关 (r=0.736, P<0.05) , IGF-1水平与抑郁评分呈现正相关 (r=0.752, P<0.05) , BDNF水平与抑郁评分呈负现相关 (r=-0.692, P<0.05) .结论 脑卒中患者早期血清BDNF、Hs-CRP及IGF-1水平的异常可能提示患者发生抑郁的风险更高.%Objective The objective of this article is to investigate the relationship between the serum level of brain-derived neurotrophic factor (BDNF) , high sensitivity C-reactive protein (hs-CRP) and insulinlike growth factors-1 (IGF-1) with post-stroke depression in stroke patients. Method A total of 100 patients with stroke in Kailuan General hospital from March2016 to February 2018 were divided into two groups according to their HAMD's scores. One was PSD group (observation group, n=43) , the other was non-PSD group (control group, n=57) . The serum level of BDNF, Hs-CRP and IGF-1 and the scores of NIHSS, ADL and mRS were compared between the two groups. To evaluate the correlation between serum level of BDNF, Hs-CRP and IGF-1 with depression.Results The level of BDNF was lower in observation group and the level of Hs-CRP and IGF-1 was higher when compared with control group (P<0.05) . The scores of NIHSS and mRS were higher and scores of ADLwere lower in observation group (P<0.05) . In addition, the serum BDNF and IGF-1 level had a positive correlation with depression (r=0.752, P<0.05) , the serum Hs-CRP level had a negetive correlation with depression (r=-0.692, P<0.05) .Conclusion The abnormal changes of BDNF, Hs-CRP and IGF-1 serum level in stroke patients may indicate a higher occurrence rate of PSD.