西比灵治疗椎基底动脉供血不足的TCD和rCBF研究

摘要

Objective： To evaluate the effect of flunarizine on cerebral blood hemodynamics and cerebral blood flow in patients with vertebrobasilar insufficiency (VBI). Methods: Tanscranial doppler (TCD) and regional cerebral blood flow (rCBF) with［133］ Xe inhalation were investigated respectively before and after 4 weeks flunarizine treatment in 22 VBI patients. Results:Compared to before treatment, the velocity of vertebral and basilar arteries was increased by flunarizine treatment, but the increase was not significant (P>0.05). Flunarizine induced a elevation of cerebral blood flow parameters, especially in brainstem-cerebellum area (P<0.05). Conclusion: Flunarizine improves cerebrovascular circulation and it's an effective drug for VBI.%目的：研究椎基底动脉供血不足(VBI)患者服用西比灵治疗后脑血流动力学和脑血流量变化。方法： 22例VBI患者西比灵治疗前及治疗4周后分别行经颅多普勒(TCD)和133氙吸入法局部脑血流量(rCBF)检测。结果：西比灵治疗后椎基底动脉系统血流速增快，但与治疗前相比无显著差异(P>0.05)；治疗后全脑血流量增高，其中脑干、小脑区脑血流量明显高于治疗前(P<0.05)。结论：西比灵能改善VBI患者脑循环，治疗VBI安全有效。