幽门螺杆菌细胞毒素相关蛋白A与脑梗死发生的关系

摘要

Objective： To explore the relationship betwenn virulent Helicobacte pylori strains infection and cerebral infarction.Methods: We assessed the prevalence of infection by srtains bearing the cytotoxin-associated gene-A(Cag-A), a strong virulence factor, in 83 patients with cerebral infaction and in 71 age-and sex matched controls with similar social background.Results: Prevalence of Helicobacter pylori infection was significantly higher in pateints than in controls(78.3% versus 56.3%, P<0.05), with an odds ratio of 2.8(95% CI, 1.46 to 5.36)adjused of age, sex, main stroke factors. Patients with cerebral infarction also had a higher prevalence of Cag-A-positive strains(45.8% versus 19.7%, P<0.01), with an adjusted odds ratio of 3.43(95%CI 1.5 to 7.24).Conclusion: It was suggested that chronic Helicobacter pylori infection, especially Cag-A-positive strains infection is and independent risk factor for cerebral infarction.%目的：探讨幽门螺杆菌(HP)及幽门螺杆菌细胞毒素相关蛋白A(CagA)与脑梗死发生的关系。方法：用酶联免疫法(ELISA)和斑点金渗滤试验(DIGFA)对83例连续住院的脑梗死患者血清中幽门螺杆菌IgG抗体(HP-IgG)和幽门螺杆菌细胞毒素相关蛋白AIgG抗体(HP-Cag-IgG)进行测定并设对照组比较。结果：脑梗死组幽门螺杆菌感染率为78.3%，幽门螺杆菌细胞毒素相关蛋白A阳性HP感染率为45.8%，而对照组分别为56.3%和19.7%，两组比较有显著差别。结论：慢性HP感染尤其是CagA阳性HP菌株感染与脑梗死的发生有关，而且可能是脑梗死的独立危险因素。