青年缺血性脑卒中患者凝血、纤溶功能测定及临床意义

摘要

Objective To investigate the changes of PT, INR,APTT, FIB, OHP, OCP and OFP in young patients with ischemic stroke. Methods A total of 46 young patients with ischemic stroke and 50 healthy controls were selected into the study. PT, INR, APTT, FIB, OHP, OCP and OFP were determined. The diagnosis value of OCP, OHP, OFP and FIB were evaluated hy ROC curve. Results FIB, OCP and OHP were elevated and OFP decreased in young patients with ischemic stroke compared to healthy controls ( p ＜ 0. 01 ). No significant difference of PT,INR and APTT were found between the two groups. The area under ROC curve( AUCROC ) of OHP( 0. 985,p ＜0. 01 ) was significantly larger than that of OCP( 0. 973, p ＜ 0. 01 ), OFP( 0. 930,p ＜ 0. 01 ) and FIB( 0. 776,p ＜ 0. 01 ). Conclusion OHP, OCP and OFP assays are simple methods which can evaluate the increased coagulation and decreased fihrinolysis ability in young patients with ischemic stroke with hetter sentivity compared to PT,INR, APTT, and FIB.%目的 研究青年缺血性脑卒中患者PT、INR、APTT、FIB、OHP、OCP及OFP变化,探讨其对青年缺血性脑卒中凝血功能异常的实验诊断意义.方法 检测46例青年缺血性脑卒中患者及50例正常对照组血浆PT、INR、APTT、FIB、OHP、OCP及OFP,比较两组间各指标差异,应用ROC曲线比较OCP、OHP、OFP与FIB对青年缺血性脑卒中的诊断准确性.结果 青年缺血性脑卒中组与对照组比较,PT、INR、APTT差异无统计学意义(p>0.05).青年缺血性脑卒中组FIB、OCP与OHP均高于对照组,OFP低于对照组,差异有统计学意义(p<0.01).ROC曲线下面积OHP最高(0.985,p<0.01),其次为OCP(0.973,p<0.01)及OFP(0.930,p<0.01),最后为FIB(0.776,p<0.01).结论 OHP、OCP及OFP可反映青年缺血性脑卒中患者凝血能力增强及纤溶能力降低,其敏感性优于PT、INR、APTT、FIB.