氟伐他汀对脑梗死患者颈动脉粥样斑块干预治疗的临床观察

摘要

目的：观察氟伐他汀对脑梗死患者血脂、炎性因子水平及颈动脉粥样硬化的影响。方法选择90例脑梗死患者，将患者随机分为3组，每组30人：A组（对照组）采用脑梗死常规治疗，氟伐他汀治疗组B组（40mg组）和C组（80mg组），B、C组在常规治疗基础上每晚分别口服氟伐他汀40mg、80mg。所有患者均于治疗前及治疗后6个月测定血脂、超敏C反应蛋白（ hs-CRP ）、基质金属蛋白酶-9（ MMP-9）水平及颈动脉粥样硬化情况。结果经过治疗6个月后， A组TC、TG、LDL-C、HDL-C、hs-CRP、MMP-9水平及颈动脉斑块积分、不稳定斑块数量、IMT较治疗前无明显改变（ P＞0．05）；B、C两组TC、TG、LDL-C、hs-CRP、MMP-9显著下降，HDL-C升高，与A组比较差异有统计学意义（ P＜0．05），其中C组TC、TG、LDL-C、hs-CRP、MMP-9水平下降更明显（ P＜0．05）；C组治疗后颈动脉斑块积分、不稳定斑块数量、IMTP明显减少，与A组比较差异有统计学意义（P＜0．05），而B组下降不明显（P＞0．05）；三组NDS较治疗前均明显降低（P＜0．05），三组之间差异有统计学意义（ P＜0．05）。结论氟伐他汀能有效降低脑梗死患者血脂、炎性因子水平，改善颈动脉粥样硬化，以80mg剂量效果显著。%Objective To observate fluorine statin cutting of cerebral infarction patients blood fat , inflammatory factor level and the influence of carotid artery atherosclerosis .Methods A total of 90 patients with cerebral infarction patients , the patients were randomly divided into three groups , each group of 30 people:group A ( control group ) with cerebral infarction conventional treatment , fluorine cutting statin therapy group and group B (40mg group) and C group (80 mg group), B and C group in often treatment on the basis of every night oral fluorine cutting respectively statin 40mg, 80mg.All of the patients before treatment and after treatment in 6 months test blood fat, inflammatory factor super sensitive c-reactive protein (hs-CRP), matrix metalloproteinase-9 (MMP-9) level and carotid atherosclerosis.Results After treatment for 6 months later, A set of TC, TG, LDL, HDL-C, hs-CRP, MMP-9 levels and carotid artery plaque score , number of unstable plaque , IMT have no obvious change compared with before treatment; B, C two groups of TC, TG, LDL-C, hs-CRP, MMP-9 decreased significantly , HDL-C increases, and group A more significant difference (P<0.05), the C group of TC, TG, LDL-C, hs-CRP, MMP-9 levels dropped more obvious ( P<0.05);Group C after treatment of carotid plaque integral , unstable plaque quantity , IMT significantly reduced , and A set of more statistical difference ( P<0.05 ) , and group B did not decrease significantly (P>0.05); Three groups of NDS is before treatment were significantly lower (P<0.05), the three groups also have statistical difference (P<0.05).Conclusion Fluoride cutting statin can effectively reduce cerebral infarction patients blood fat , inflammatory factor level , improve the carotid artery atherosclerosis , with 80 mg dose effect is remarkable , and worth popularization and application .