目的：：总结特利加压素联合生长抑素治疗肝硬化失代偿期并急性上消化道大出血的临床效果。方法：选取44例肝硬化失代偿期并急性上消化道大出血患者,按照随机数字表法分为观察组和对照组各22例。对照组给予特利加压素治疗,观察组给予特利加压素联合生长抑素治疗。给药48h后观察止血效果,比较再出血、止血时间、病死率和住院时间等。结果：观察组止血总有效率为95.4%,对照组止血总有效率为72.7%,差异无统计学意义(P>0.05)。观察组输血量、止血时间和住院时间均显著少于对照组(P0.05)。治疗后观察组患者的血压、尿量恢复时间及大便隐血转阴速度均明显快于对照组(P0.05)。结论：特利加压素联合生长抑素治疗肝硬化失代偿期并急性上消化道大出血具有止血效果好、止血时间快、安全性高等优点,同时可缩短住院时间,降低输血量。%Objective:To analyze the clinical effects of terlipressin combined with somatostatin in the treatment of decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract. Methods:Forty-four patients with decompensated liver cirrhosis complicated with acute hemorrhage of upper digestive tract were randomly divided into the experimental group and control group according to random number table method ( 22 cases each group ) . The control group and experimental group were treated with terlipressin and terlipressin combined with somatostatin,respectively. The hemostatic effects,rebleeding,hemostasis time,mortality and hospitalization time between two groups were compared after 48h of treatment. Results:The effective rates of hemostasis in experimental group and control group were 95. 4% and 72. 7%,respectively,the difference of which was not statistical significance(P>0. 05). The blood transfusion volume,hemostasis time and hospitalization time in experimental group were significantly less than those in control group(P0. 05). After treatment,the recovery time of blood pressure and urine volume,and speed of stool occult blood turning negative in experimental group were significantly faster than those in control group(P0. 05). Conclusions:Terlipressin combined with somatostatin in treating liver decompensation complicated with acute upper gastrointestinal hemorrhage is high hemostatic effectiveness,quick hemostasis time and high safety,which can short hospitalization time and decrease blood transfusion volume.
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