盐酸羟考酮在糖尿病患者经鼻插管健忘镇痛慢诱导中的应用

摘要

Objective:To investigate the effects of intravenous injection of 0. 1 mg/kg of oxycodone on the hemodynamics and stress response in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter. Methods:Eighty stage ASA Ⅰ to Ⅱdiabetics(38 to 60 years old) were randomly divided into the oxycodone group(group O) and fentanyl group(group F)(40 cases each group). The group O and group F were treated with 0. 1 mg/kg of oxycodone and 1 μg/kg of fentanyl by intravenous injection, respectively. The levels of SBP,DBP,HR,Epinephrine and Norepinephrine in two groups were measured before anesthesia induction (T0),tracheal tube through choana(T1),at the time of intubation(T2),after 3 min of intubation(T3) and after 10 min of intubation (T4). Results:Compared before operation,the SBP level in two group increased at T1 and T2(P0. 05),and decreased after operation(P0.05),术后有所下降(P<0.05),F组术中上升(P<0.05),术后下降(P<0.05);2组HR均出现术中上升(P<0.05),术后下降的现象(P<0.05),但F组HR升高幅度大于O组(P<0.05);比较不同时间点的肾上腺素和去甲肾上腺素水平,2组均表现为T2时间点后上升趋势(P<0.05),且F组上升幅度高于O组(P<0.05~P<0.01).结论:0.1 mg/kg盐酸羟考酮用于糖尿病患者健忘镇痛慢诱导气管插管中,维持了血流动力学稳定,显著抑制了机体应激反应,增加了2型糖尿病患者非心脏手术围术期安全性.