PRC2成分SUZ12在结直肠癌组织中的表达及其与临床病理特征的相关性

摘要

目的：：探讨并研究多梳抑制复合物2(PRC2)成分SUZ12在结直肠癌组织中的表达情况及其与临床病理特征的相关性。方法：选择85例行腹腔镜结直肠癌切除术的患者为研究对象，术中收集所有患者手术切除后的结直肠癌病理标本，患者术前均未行放化疗，同时另取距离癌组织边缘15 cm的癌旁正常组织为对照组。测定结直肠癌组织及正常组织内的SUZ12蛋白含量，根据细胞核阳性染色强度和阳性细胞所占比例，评价SUZ12阳性表达分数及在结直肠癌组织中的表达水平。结果：左半结肠癌组、横结肠癌组、右半结肠及乙状结肠癌组、直肠癌组与其相应的对照组多梳蛋白SUZ12的阳性标记分数均增加( P0.05)。结论：SUZ12蛋白可作为评价肿瘤恶性程度的指标，对早期诊断结直肠癌、改善治疗方案、提高患者生存时间至关重要。%Objective:To explore expression of the SUZ12 of PRC2 subunit in colorectal cancer tissue,and its correlation with clinical pathological features. Methods:Eighty-five patients treated with laparoscopic colorectal cancer resection were investigated,the colorectal cancer specimen during surgical resection was collected,and all patients were not treated with chemoradiation therapy before operation. The normal tissue distance from carcinoma tissue edge for 15 cm was set as the control group. The protein content of SUZ12 in colorectal cancer tissue and normal tissue were determined. The expression level of SUZ12 in colorectal cancer tissue was evaluated according to the proportions of positive staining intensity and positive cell nucleus. Results:The positive marking scores of comb SUZ12 protein in left half colon cancer group,transverse colon cancer group,right half colon,sigmoid colon cancer,rectal cancer group and control group increased(P0. 05). Conclusions:SUZ12 protein can be used as the evaluation index of tumor malignant degree,which is crucial in the early diagnosis of colorectal cancer,improving treatment and prolonging the survival time of patients.