目的：观察 GEMOX 方案联合同步放疗治疗Ⅲ期食管癌的疗效及安全性。方法94例Ⅲ食管癌患者随机均分为2组，每组47例，对照组患者仅给予 GEMOX 方案治疗，而观察组在对照组治疗的基础上加用三维适形放疗。结果观察组有效率为82.98%，高于对照组的44.68%（χ2=16.556，P =0.001）；2组白细胞减少、血小板减少及恶心呕吐发生率比较差异无统计学意义（P >0.05）；观察组放射性食管炎、放射性肺炎分别为33例、7例，而对照组因未行放疗而无放射性食管炎、放射性肺炎病例（χ2=50.852，P <0.001；χ2=7.563，P =0.006）。结论 GEMOX 方案联合同步放疗治疗Ⅲ期食管癌的疗效明显优于单一 GEMOX 方案，但其导致放射性食管炎、放射性肺炎可能对患者造成一定伤害。%Objective To observe the efficacy and safety of GEMOX regimen combined with concurrent radiothera-py in the treatment of stage Ⅲ esophageal cancer. Methods Ninety-four patients with stage Ⅲ esophageal cancer were randomly divided into the control group and the observation group,47 patients in each group. The patients in the two groups were treated with GEMOX regimen at the same time,the patients in the observation group were also treated with three-dimensional conformal radiotherapy. Results The effective rate in the observation group was 82. 98% ,and was 44. 68% in the control group(χ2 = 16. 556,P = 0. 001). There was no significant differences in the incidences of leu-kopenia,thrombocytopenia,nausea and vomiting between the two groups( P > 0. 05);the incidences of radiation esophagitis and radiation pneumonitis in the observation group were obviously higher than those in the control group (χ2 = 50. 852,P < 0. 001;χ2 = 7. 563,P = 0. 006). Conclusion The efficacy of GEMOX regimen combined with con-current radiotherapy for stage Ⅲ esophageal cancer is significantly better than the single GEMOX regimen,but the radi-ation esophagitis and radiation pneumonitis are observed.
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