原发中枢神经系统淋巴瘤40例治疗与预后分析

摘要

目的 比较不同治疗方法对原发中枢神经系统淋巴瘤患者的有效性及安全性.方法 收集40例原发中枢神经系统淋巴瘤患者,分为3组,其中单纯手术组10例、手术联合化疗组15例、手术联合放化疗组15例,对3组进行生存分析比较.结果 随访7~53个月,中位生存时间手术联合放化疗组(45个月)和手术联合化疗组(30个月)高于单纯手术组(17个月),差异均有统计学意义(P均<0.05).3 a生存率手术联合放化疗组(72.2%)高于手术联合化疗组(40.8%)和单纯手术组(27.3%,P均<0.05).结论 手术联合放化疗可有效治疗原发中枢神经系统淋巴瘤,且患者耐受性好.%Objective To determine efficacy and safety of different treatments for primary centralnervoussystemlymphoma.Methods Atotal of 40 patients were surveyed,and were divided into three groups: 10 cases in the surgery alone group,15 cases in the surgery combined with chemotherapy group,15 cases in the surgery combined with chemo-radiotherapy group.The survival was analyzed among the threegroups.Results After the follow-up of 7-53 months,the median survival time of the patients in the surgery combined with chemo-radiotherapy group(45 months) and the surgery combined with chemotherapy group(30 months) were higher than that in the surgery alone group(17 months,P<0.05);the 3-year overall survival rate of the patients in the surgery combined with chemo-radiotherapy group(72.2%) was higher than those in the surgery combined with chemotherapy group(40.8%) and the surgery alone group(27.3%,P<0.05).Conclusion Surgery combined with chemo-radiotherapy is safe and effective for the primary central nervous system lymphoma.