芝芪菌质水提物抗抑郁作用研究

摘要

[目的]探讨通过"固体双向发酵"工程技术生产的药性菌质的抗忧郁功效.[方法]将雄性ICR小鼠随机分为5组,即阴性对照组(0.9%生理盐水)、阳性对照组(市售盐酸氟西汀)、高剂量组(690.0mg/kg)、中剂量组(345.0mg/kg)和低剂量组(172.5mg/kg),在灌胃给予受试物15d后对各组小鼠进行开场试验(OFT)、悬尾试验(TST)和强迫游泳试验(FST),探讨芝芪菌质对小鼠行为学的影响.[结果]中剂量组芝芪菌质和阳性对照组能显著缩TST和FST小鼠悬尾和游泳不动时间,对小鼠开场行为无显著影响.[结论]芝芪菌质水提物具有一定的抗抑郁作用.%[Objective] To explore the antidepressant effects of medicinal fungal substance which was produced from the engineering technology of "bidirectional solid fermentation". [Method] Male ICR mice were randomly subdivided into five groups namely negative control group (0.9% normal saline) .positive control group (fluoxetine hydrochloride purchased from market) .high dosage group(690.0 mg/kg) .middle dosage group (345.0 mg/kg )and low dosage group(172.5 mg/kg).The mice were given corresponding solution per day respectively. Fifteen days later,they were subjected to the open-field test (OFT) .tails suspension test (TST) and forced swimming test (FST ) .evaluating the effects of solution extracted from Zhiqi medicinal fungal substance on mice behavior. [Result] The extracts of Zhiqi medicinal fungal substance significantly reduced the immobility duration of mice in TST and FST after exercised in positive control group and middle dosage group,while it had no effect on open field behavior of mice. [Conclusion] The solution extracted from Zhiqi medicinal fungal substance possesses definite antidepressant properties.