美洲大蠊对免疫性肝纤维化大鼠肝功能的影响

摘要

[目的]探讨美洲大蠊对免疫性肝纤维化大鼠肝功能的影响.[方法]采用腹腔注射猪血清法诱导大鼠免疫性肝纤维化模型,在造模的同时分别用不同剂量的受试药物(美洲大蠊总提取物和美蠊氨)干预,以秋水仙碱为阳性对照药,分别于试验第4周和第12周结束时取血检测血清中ALT(谷丙转氨酶)、AST(谷草转氨酶)和TBIL(总胆红素)的含量,并在第12周结束时处死大鼠,取肝脏称重并计算肝脏指数.[结果]试验4周后,美洲大蠊总提取物能明显降低大鼠血清中ALT、AST、TBIL的含量.试验12周后,美蠊氨能明显降低大鼠血清中ALT、AST、TBIL的含量,但此时美洲大蠊总提取物对3个指标的影响不大.[结论]美洲大蠊对免疫性肝纤维化具有一定的防治作用,能明显改善肝功能.%[ Objective] To study the effect of Periplaneta americana on liver function of rats with immune hepatic fibrosis. [ Method] The immune hepatic fibrosis model was induced by porcine serum, different dosages of drugs (the total extracts from Periplaneta americana and Meili-anan) were administered to the rats, colchicine was took for the positive drug. After 4 weeks and 12 weeks, the atanine aminotransferase (ALT) , aspartate aminotransferase (AST) and total bilirubin (TBIL) in the serum of the rats were detected and the hepatic index after 12 weeks was calculated. [ Result] After 4 weeks, the serum levels of ALT, AST and TBIL was decreased by the total extracts from Periplaneta amsricana; after 12 weeks, the serum levels of ALT, AST and TBIL was decreased by Meilianan, but hardly influenced by the total extracts from Periplaneta americana. [Conclusion] Periplaneta americana can prevent the immune liver fibrosis to a certain extent and improve the liver function obviously.