Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease characterized by arthrosynovitis.The recurrent attacks of synovitis may lead to destruction of articular cartilages and bones,and dysfunction of joints.The symptoms are often symmetrical,affecting the small joints such as the interphalangeal joints,wrists,and the metatarsophalangeal joints.The large joints including elbow,shoulder,ankle,and knee may also be involved in severe cases.
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