雾化吸入布地奈德混悬液联合沙丁胺醇液治疗慢性阻塞性肺疾病急性加重期临床观察

摘要

Objective To observ the safaty and the therapy effect of budesonide suspension for inhalation(budesonide) combined with salbutamol sulfate respirator solution(Ventolin) on chronic obstructive pulmonary disease(AECOPD) at acute exacerbations phase,and evaluate the clinical.Methods 120 patients with AECOPD were randomly divided into 2 groups(treatment group and control group).The treament group were given budesonide suspension for inhalation combined with salbutamol sulfate respirator solution for 10~14 days,respiratory function and diffcalty of breathing were determined after treatment.Results Before treatment,the treatment group had no statistical significance and dyspnea score,lung function and blood gas analysis indexes difference(P>0.05);after the treatment group and the control group of dyspnea,pulmonary function and blood gas analysis indexes of the differences were statistically significant(P<0.05).Conclusion Budesonide suspension for inhalation(budesonide) combined with salbutamol sulfate respirator solution(ventolin) had no side effect.may effectively relieve the symptoms of AECOPD.It’s the choice therapy for AECOPD.%目的：观察布地奈德混悬液联合沙丁胺醇液治疗慢性阻塞性肺疾病急性加重期（AECOPD）的疗效安全性，评价其临床应用价值。方法：将120例AECOPD患者随机分为治疗组与对照组，治疗组在常规治疗的基础上加用布地奈德混悬液和沙丁胺醇液吸入10～14 d，观察治疗组与对照组肺功能和呼吸困难分级转归情况。结果：治疗前治疗组与对照组呼吸困难评分、肺功能与血气分析各项指标差异均无统计学意义（P＞0.05）；治疗后治疗组与对照组呼吸困难评分、肺功能与血气分析各项指标差异均有统计学意义（P＜0.05）。结论：布地奈德混悬液与沙丁胺醇液联合雾化吸入无明显不良反应及临床禁忌证，安全有效，可作为治疗COPD急性发作常规用药之一。