静脉泵入特布他林缓解小儿哮喘重度急性发作的疗效观察

摘要

Objective To observe the effects of terbutaline sulfate injection on severe exacerbation in pediatric asthma. Method 36 chil-dren who suffered severe exacerbation of asthma wre randomly divided into two groups with 18 cases in each group. The control group was ad-ministered aerosol inhalation with terbutaline sulfate and ipratropium bromide,in addition of prednisolone injection 1~2 mg/( kg·d),maxi-mal bolus no more than 60 mg for overweight children. The Observation group was injected intravenously 0. 0025 mg/min while terbutaline sul-fate 5. 0mg was diluted by 100ml 0. 9‰ sodium chloride. The symptoms of asthma and the parameters of pulmonary were compared after 1 hour. Results The total effective rate and lung function in the observation group was significantly higher than the control group(P<0. 05). Conclusion Terbutaline sulfate injection can attenuate severe exacerbation in pediatric asthma,improve respiratory function in children and the total effectiove rate.%目的：观察静脉泵入特布他林缓解小儿哮喘重度急性发作的疗效。方法：将36例哮喘重度急性发作的患儿随机分组（n＝18），对照组给予特布他林加异丙托溴铵联合雾化吸入，泼尼松龙静脉注射1~2 mg/（kg·d），年长儿单次不超过60 mg，疗程3~5 d；观察组在以上治疗基础上给予特布他林0.5 mg加入生理盐水100 ml中，以0.0025 mg/min的速度缓慢静脉泵入。对照组用等量生理盐水静脉泵入。观察两组患儿给药1 h后发作症状和呼吸功能参数，包括喘鸣，用力呼吸、意识模糊、PDF‰、PaO2、PCO2。结果：观察组临床总有效率和肺功能指标明显高于对照组（P<0.05）。结论：静脉泵入特布他林抢救小儿急性重度哮喘，明显改善了患儿的呼吸功能，提高了治疗的总有效率。