目的：探讨抗肿瘤药物粒子支架在食道恶性梗阻中的应用。方法：选取90例食道恶性梗阻的患者，根据自愿原则分为三组，A 组患者采用普通支架治疗，B 组患者采用125I 放射性粒子支架治疗，C 组患者采用5－Fu 化疗粒子支架治疗。术中、术后观察、统计并随访支架置入的成功率、吞咽困难缓解率、并发症发生率及1年生存期等。结果：三组患者支架置入成功率均为100％，短期吞咽困难缓解率为100％，术后再狭窄等并发症发生率三组分别为28.9％、27.1％和26.8％，差异均无统计学意义（P ＞0.05）。而三组患者术后平均生存期分别为（3.2±0.6）个月、（6.6±0.7）个月和（9.9±0.7）个月，差异有统计学意义（P ＜0.05）。结论：抗肿瘤药物粒子支架较普通支架能明显延长患者的生存期。临床应用安全、可行。%Objective To investigate the anticancer drug particles stents in malignant esophageal obstruction in.Method 90 cases of malignant esophageal obstruction inpatients were selected and divided into three groups on a voluntary basis,A group of pa-tients with ordinary stents,B group treated with 125I radioactive particles stents,C group treated with 5 -Fu chemotherapy particle stents.Rate of stent success placement,dysphagia response rate,incidence of complications and 1 -year survival period were ob-served、analyzed and follow -up during operative and postoperative period.Results Success rate in three groups were 100%,short-term relief of dysphagia was 100%,postoperative complications such as restenosis rate in three groups were 28.9%,27.1% and 26.8%,respectively,the difference was not statistically significant (P >0.05).The three groups of patients after an average surviv-al time was (3.2 ±0.6)months,(6.6 ±0.7)months and (9.9 ±0.7)months,respectively,the difference was statistically signifi-cant (P <0.05).Conclusion Antineoplastic particle stent compared with ordinary stents could significantly prolong the survival of patients.Clinical application of safe and feasible.
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