苍苓止泻口服液联合双歧杆菌四联活菌片治疗小儿非感染性腹泻

摘要

Objective To investigate the Cangling antidiarrheal oral liquid combined with bifid Bacillus tetragenus lacto-bacillus tablets in the treatment of children with non infectious diarrhea clinical effect .Methods Selected 130 cases of non infectious diarrhea were randomly divided into observation group and control group .Control group was treated with conven-tional therapy ,the observation group in the control group on the basis of the Cangling antidiarrheal oral liquid combined with bifid Bacillus tetragenus live bacteria tablets in the treatment of and compared between the two groups the total efficiency , diarrhea stopping time ,dehydration ,correct time ,hospitalization time and serum IL-6 ,IL-7 ,fecal SIgA level .Results The total effective rate in the observation group was 96 .92% ,higher than that of the control group of 86 .15% ,the difference is statistically significant ( P<0 .05 );observation group of children with diarrhea stops time ,dehydration ,correct time and hospitalization time were lower than those in the control group ,the difference is statistically significant ( P<0 .05 );72 hours treatment ,the observation group ,IL-6 and IL-7 levels significantly lower than that in control group ,the difference is statisti-cally significant ( P<0 .05 );treatment group fecal SIgA levels higher than that of the control group ,the difference is statisti-cally significant ( P<0 .05 ) .Conclusion Bifidobacterium quadruple live bacteria tablets combined Cang Ling antidiarrhea oral liquid can effectively shorten the non infectious diarrhea in children with diarrhea time ,dehydration recovery time and hospitalization time ,reduce IL-6 and IL-17 levels ,increased intestinal SIgA level ,reduce the inflammatory response in chil-dren ,and defense against pathogen invasion ,and treatment of children with non infectious diarrhea .%目的：探讨苍苓止泻口服液联合双歧杆菌四联活菌片治疗小儿非感染性腹泻的临床效果。方法选取130例非感染性腹泻患儿，随机分为观察组和对照组。对照组采用常规方法治疗，观察组在对照组基础上采用苍苓止泻口服液联合双歧杆菌四联活菌片进行治疗，比较2组的总有效率、腹泻停止时间、脱水纠正时间、住院时间及血清IL－6、IL－7及粪便SIgA水平。结果观察组总有效率为96.92％，高于对照组的86.15％，差异有统计学意义（ P＜0.05）；观察组患儿腹泻停止时间、脱水纠正时间及住院时间均较对照组短，差异有统计学意义（ P＜0.05）；治疗72 h ，观察组IL－6和IL－7水平明显较对照组低，差异有统计学意义（ P＜0.05）；治疗组粪便中SIgA水平高于对照组，差异有统计学意义（ P＜0.05）。结论双歧杆菌四联活菌片联合苍苓止泻口服液能有效缩短非感染性腹泻患儿腹泻时间、脱水恢复时间和住院时间，降低IL－6和IL－17水平，增加肠道SIgA水平，减轻患儿体内炎症反应，防御病原体侵入，从而治疗小儿非感染性腹泻。