Objective To study the clinical efficiency and evaluate the security of Total flavonoids of propolis(TFP) pills for the treatment of chronic stable angina (syndrome of qi deficiency and blood stasis ) by motion tablets .Methods Sixty four patients with stable angina pectoris type in CHD with the syndrome of qi deficiency and blood stasis were selected and divid-ed randomly into two groups:Treatment group ( n=48 ) treated with TFP pills;Control group ( n=16 ) treated with TFP analog agent .The trival lasted three months .Observing and comparing clinical symptoms effect changes between two groups and evaluate their security .Results Treadmill test:after treating ,total time of exercise ,the maximum HR during exercise test ,metabolic equivalent of treatment group were improved significantly than before ,with statistical difference ( P<0 .05 ) . The total time of exercise in treatment group was significantly longer than that in control group ,with statistical difference ( P<0 .05 ) .Alleviating angina pectoris:after treatments ,treatment group achieved 16 .67% obvious curative rate respec-tively ,and results effective rate of this group was 45 .83% .TCM symptoms curative effect ,symptom curative effect of TCM treatment group patients total effective rate was 75 .00% ;The control group total effective rate 25 .00% .After studying , anginal stability ,satisfaction on treatment ,and cognitive level on disease were higher than pre-treatment ,with statistical dif-ference ( P<0 .05 ,P<0 .01 );satisfaction on treatment in treatment group was higher than control group ,with statistical difference ( P<0 .05) .Conclusion Total flavonoids of propolis (TFP) pills have favorable clinical curative effect on angi-na pectoris of coronary heart disease .TFP can improve blood supply of cardiac muscle ,is effective in alleviating angina pec-toris and improving clinical symptoms ,and can enhance heart reserve ability ,raise the quality of life .%目的:探讨蜂胶总黄酮滴丸治疗慢性稳定性心绞痛(气虚血瘀证)疗效和安全性。方法选择符合慢性稳定性心绞痛诊断,并且辨证为气虚血瘀证患者64例,采用随机、双盲法分为试验组和对照组。试验组48例服用蜂胶总黄酮滴丸,3次/d ,1袋/次;对照组16例服用蜂胶总黄酮滴丸模拟剂,3次/d ,1袋/次。试验为期3个月,分别观察2组的临床疗效及其安全性。结果运动平板试验中,试验组患者治疗12周后运动完成时间、最大运动心率、运动耐量较治疗前均明显升高,有统计学意义( P<0.05);试验组患者运动完成时间明显高于对照组,有统计学意义( P<0.05)。在缓解心绞痛方面,蜂胶总黄酮滴丸显效率为16.67%,总有效率为45.83%;中医症状疗效方面,试验组患者中医症状疗效总有效率75.00%,对照组总有效率25.00%。2组之间总有效率、有效率比较有统计学意义( P<0.01,P<0.05)。西雅图量表调查中,试验组患者治疗后心绞痛稳定状态、治疗满意程度、疾病认识程度积分较治疗前均升高,有统计学意义( P<0.05,P<0.01);试验组患者治疗满意程度积分明显高于对照组,有统计学意义( P<0.05)。结论蜂胶总黄酮滴丸治疗气虚血瘀型慢性稳定性心绞痛疗效明显,安全性高,能有效改善心肌供血,缓解心绞痛,改善临床症状,提高心脏储备能力。蜂胶总黄酮滴丸能够缓解冠心患者身心症状,提高其生活质量。
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