首页> 中文期刊> 《吉林中医药》 >蜂胶总黄酮滴丸治疗慢性稳定性心绞痛气虚血瘀证疗效及安全性研究

蜂胶总黄酮滴丸治疗慢性稳定性心绞痛气虚血瘀证疗效及安全性研究

         

摘要

Objective To study the clinical efficiency and evaluate the security of Total flavonoids of propolis(TFP) pills for the treatment of chronic stable angina (syndrome of qi deficiency and blood stasis ) by motion tablets .Methods Sixty four patients with stable angina pectoris type in CHD with the syndrome of qi deficiency and blood stasis were selected and divid-ed randomly into two groups:Treatment group ( n=48 ) treated with TFP pills;Control group ( n=16 ) treated with TFP analog agent .The trival lasted three months .Observing and comparing clinical symptoms effect changes between two groups and evaluate their security .Results Treadmill test:after treating ,total time of exercise ,the maximum HR during exercise test ,metabolic equivalent of treatment group were improved significantly than before ,with statistical difference ( P<0 .05 ) . The total time of exercise in treatment group was significantly longer than that in control group ,with statistical difference ( P<0 .05 ) .Alleviating angina pectoris:after treatments ,treatment group achieved 16 .67% obvious curative rate respec-tively ,and results effective rate of this group was 45 .83% .TCM symptoms curative effect ,symptom curative effect of TCM treatment group patients total effective rate was 75 .00% ;The control group total effective rate 25 .00% .After studying , anginal stability ,satisfaction on treatment ,and cognitive level on disease were higher than pre-treatment ,with statistical dif-ference ( P<0 .05 ,P<0 .01 );satisfaction on treatment in treatment group was higher than control group ,with statistical difference ( P<0 .05) .Conclusion Total flavonoids of propolis (TFP) pills have favorable clinical curative effect on angi-na pectoris of coronary heart disease .TFP can improve blood supply of cardiac muscle ,is effective in alleviating angina pec-toris and improving clinical symptoms ,and can enhance heart reserve ability ,raise the quality of life .%目的:探讨蜂胶总黄酮滴丸治疗慢性稳定性心绞痛(气虚血瘀证)疗效和安全性。方法选择符合慢性稳定性心绞痛诊断,并且辨证为气虚血瘀证患者64例,采用随机、双盲法分为试验组和对照组。试验组48例服用蜂胶总黄酮滴丸,3次/d ,1袋/次;对照组16例服用蜂胶总黄酮滴丸模拟剂,3次/d ,1袋/次。试验为期3个月,分别观察2组的临床疗效及其安全性。结果运动平板试验中,试验组患者治疗12周后运动完成时间、最大运动心率、运动耐量较治疗前均明显升高,有统计学意义( P<0.05);试验组患者运动完成时间明显高于对照组,有统计学意义( P<0.05)。在缓解心绞痛方面,蜂胶总黄酮滴丸显效率为16.67%,总有效率为45.83%;中医症状疗效方面,试验组患者中医症状疗效总有效率75.00%,对照组总有效率25.00%。2组之间总有效率、有效率比较有统计学意义( P<0.01,P<0.05)。西雅图量表调查中,试验组患者治疗后心绞痛稳定状态、治疗满意程度、疾病认识程度积分较治疗前均升高,有统计学意义( P<0.05,P<0.01);试验组患者治疗满意程度积分明显高于对照组,有统计学意义( P<0.05)。结论蜂胶总黄酮滴丸治疗气虚血瘀型慢性稳定性心绞痛疗效明显,安全性高,能有效改善心肌供血,缓解心绞痛,改善临床症状,提高心脏储备能力。蜂胶总黄酮滴丸能够缓解冠心患者身心症状,提高其生活质量。

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