Objective To investigate the effect of modified Cangfu Daotan decoction on sex hormone levels and pregnancy rate of obese women with polycystic ovary syndrome. Methods 120 obese women with polycystic ovary syndrome were selected as the research object. According to the random number table method, patients were randomly divided into the study group (n = 60) and the control group (n = 60). 120 patients were all given metformin hydrochloride enteric coated tablets. On this basis, the study group patients were given modified Cangfu Daotan decoction. After treatment, the obesity related indexes, sex hormone l evels, menstrual cycle, ovulation, pregnancy and efficacy were compared between the two groups. Results After treatment, the body weight, BMI, waist / hip circumference, leptin level and T, PRGE, PRL and GnRH level in the study group were significantly were decreased and E2, SHBG, cor, ACTH, CRH were significantly increased, showing statistical difference compared with those before treatment (P<0.05). Moreever, the degree of improvement of these levels in in the study group were better than those of the control group (P<0.05). The normal ovulation rate, pregnancy rate and total effective rate in the study group were higher than those in the control group, indicating significantly statistical difference (P< 0.05).Conclusion Cangfu Daotan decoction can decrease the body weight,improve the balance of sex hormone level and increase the pregnancy rate of obese patients with polycystic ovary syndrome.%目的 探讨加减苍附导痰汤对肥胖型多囊卵巢综合征患者性激素水平及受孕率的影响.方法 选择120例肥胖型多囊卵巢综合征患者为研究对象,根据随机数字表法分为研究组和对照组各 60例,120例多囊卵巢综合征患者均给予盐酸二甲双胍肠溶片,在此基础上,研究组患者给予苍附导痰汤.比较治疗后2组患者肥胖相关指标、性激素水平、月经周期、排卵情况、受孕情况和疗效.结果 治疗后,研究患者的体质量、BMI、腰围/臀围、瘦素水平、T、PRGE、PRL和GnRH水平均明显降低,E2、SHBG、Cor、ACTH、CRH均明显升高,且与治疗前比较差异有统计学意义(P<0.05),且研究组体质量、BMI、瘦素水平、T、GnRH、E2、SHBG、Cor、ACTH和CRH水平的改善程度均优于对照组(P<0.05).研究组患者的正常排卵率、受孕率和总有效率均高于对照组,差异具有统计学意义(P<0.05).结论 苍附导痰汤能降低肥胖型多囊卵巢综合征的体质量,改善性激素水平的平衡状态,提高受孕率.
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