Objective To discuss the clinical basis and strategy of LC timing choice after EST. Methods 30 patients of cholecystolithiasis and choledocholithiasis were divided into two groups randomly with 15 cases each. In the experimental group , LC operations were performed based on whether the complications of EST may affect LC or not,while in the control group,LC op-erations were performed only after the complete disappearance of clinical symptoms and all the examination results went back to normal. The operation time and complications of LC were compared between these two groups. Results There was no significant difference of complications incidence and recovery time between groups,whereas the interval time of LC was significantly short-ened in the experimental group,so that the length of stay and the medical cost were definitely reduced. Conclusion The optimal timing of LC could be based on whether the complications of EST may affect LC or not.%目的：探讨经十二指肠乳头括约肌切开取石(endoscopic sphincterotomy,EST)术后再行腹腔镜胆囊切除手术( la-paroscopic cholecystectomy,LC）可遵循的临床依据和策略。方法选择30例明确诊断胆囊结石并胆总管结石患者，随机分为2组，每组15例，研究组按照以EST 后可能出现影响LC 进行的并发症为参考依据来选择LC 的手术时机，对照组按照通常EST 后临床症状完全消失、各项检查结果恢复正常时行LC。比较两组EST 后行LC 的手术时间选择、主要并发症情况。结果两组在LC术后并发症、恢复时间上无显著差异，研究组在EST后再行LC手术的间隔时间明显缩短（P<0.05），总的住院日和医疗费用有明显减少。结论按照以EST 后可能出现影响LC 进行的并发症为参考依据来选择LC 的最佳手术时机是切实可行的一条路径。
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