右美托咪定对颅内血管重建术患者围手术期应激反应的影响

摘要

目的：探讨右美托咪定对颅内血管重建术患者围手术期应激反应的影响。方法选取我院收治的颅内血管重建术患者40例，随机分为对照组和观察组，对照组使用等容量生理盐水进行持续输注，观察组使用右美托咪定进行持续静脉输注，对比分析两组患者的血流动力学和去甲肾上腺素（NE）、肾上腺素（E）与皮质醇（COR）含量水平情况。结果在拔管T3时间点中，观察组患者在平均动脉压MAP和心率与基础MAP、心率相比出现明显升高，差异具有统计学意义（P＜0.05），但观察组MAP、心率变化幅度小于对照组，组间对比有统计学意义（P＜0.05）。在T2与T4时间点，观察组去甲肾上腺素（NE）、肾上腺素（E）与皮质醇（COR）水平均明显优于对照组，差异显著，存在统计学意义，P＜0.05。结论右美托咪定能够有效减轻颅内血管重建术患者围手术期应激反应，保证血流动力学的稳定，对患者的脑部起到保护作用，其临床价值较高。%Objective To investigate the effect of dexmedetomidine on intracranial vascular reconstruction effect of periopera-tive stress response of patients. Methods 40 cases were treated in our hospital from intracranial vascular reconstruction surgery , were randomly divided to control group and the observation group and the control group with the same volume of saline infusion , the observation group use of dexmedetomidine continuous intravenous infusion,comparative analysis of two groups of patients with hemodynamic and to norepinephrine(NE),epinephrine (E) and cortisol (COR) levels in the situation. Results In pull tube time T3, observation of patients in the mean arterial pressure map and HR and map,heart rate significantly increased compared to a,the difference is statistically significant (P<0.05),but the observation group map,heart rate variation is less than the control group, group compared with statistical significance (P<0.05). In the T2 and T4 time points,the observation group of norepinephrine (NE), epinephrine (E) and cortisol (COR) levels were significantly better than the control group,significant difference,statistically signifi-cant,P<0.05. Conclusion Dexmedetomidine set can effectively reduce intracranial revascularization in patients with perioperative stress reaction and ensure the stability of hemodynamics,the patient's brain to protect,its clinical value is higher.