18F-FLT PET/CT显像在恶性肿瘤诊断中的应用价值

摘要

Objective to evaluate the usefulness of 18F-FLT PET/CT fusion imaging in different carcinomas. Methods Thirty-one patients with histologically proven carcinoma underwent whole-body 18F-FLT PET/CT scan. The maximum standard uptake value(SUVmax) and nean SUV (SUVmean) for 18F-FLT were calculated. Results In all patients,18F-FLT uptake could be detected in the primary tumor or metastasis site. The SUVmax and SUVmean for 18 F-FLT in 100 lesions of 31 patients with carcinoma were ( 5. 20 ± 2. 79 ) and (4. 35 ± 2.38), respectively. The SUVmax and SUVmean of metastasis lesions of lung cancer were (2. 29 ± 1. 54) and ( 1.72 ± 1.09), which were lower than those of nasopharyngeal carcinoma lesions (P＜ 0. 05). Conclusion 1s F-FLT PET/CT imaging provides an useful supplementary information that assists the diagnosis of carcinomas.%目的 探讨3'-脱氧-3'-18F-氟代胸苷(18F-FLT)PET/CT显像在恶性肿瘤诊断中的应用价值.方法 对31例恶性肿瘤患者行18F-FLT PET/CT显像,分析18F-FLT PET/CT显像中病灶感兴趣区(ROI)最大标准摄取值(SUVmax)和平均标准摄取值(SUVmean)与肿瘤类型、病理类型和分期的关系.结果 18F-FLT PET/CT显像图像质量好,病灶显影清晰.31例共发现100处病灶18F-FLT高摄取,SUVmax为(5.20士2.79),SUVmean为(4.35士2.38);其中,肺癌患者淋巴结转移4处,SUVmax为(2.29士1.54),SUVmean为(1.72士1.09),较鼻咽癌组低(P<0.05);鼻咽癌不同病理类型间SUV值差异无统计学意义(P>0.05).结论 10F-FLT PET/CT显像能清晰显示鼻咽癌、肺癌、淋巴瘤、喉癌、肾盂癌原发病灶及转移病灶,有临床应用价值.