Objective To study the sensitivity and specificity of the ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placenta growth factor (PLGF) for predicating the development of preeclampsia.Methods Serum levels of sFlt-1 and PLGF were detected by ELISA in 122 women with high risk for preeclampsia(group A) and 230 normal pregnant women(group B),who were in 16 to 20 weeks of pregnancy.The ratio of sFlt-1 to PLGF was calculated.Results Serum sFlt-1 in group A was (308.5±85.5) ng/L,which was higher than (265.3±98.6) ng/L in group B(P＜0.01).The PLGF level of group A was similar to that of group B [(30.8±9.0) ng/L vs.(30.4±11.6) ng/L] (P＞0.05).The ratio of sFlt-1 to PLGF in group A was positively correlated to body mass index (BMI) (r=0.724,P＜0.01).When the ratio was ＞ 11.0 in 16 to 20 weeks of pregnancy,the sensitivity and specificity in predicating the development of preeclampsia in group A were 97.9％ and 97.1％,respectively,which were 84.0 ％ and 59.1 ％ in group B.Conclusion The ratio of sFlt-1 to PLGF as an early marker for predicating development of preeclarnpsia is more valuable in the pregnant women with high risk for preeclampsia than in those with normal pregnancy.%目的 探讨血清可溶性血管内皮生长因子受体1(sFlt-1)联合胎盘生长因子(PLGF)预测孕妇子痫前期的敏感性和特异性.方法 用ELISA检测352例子痫前期孕妇在孕16-20周时血清sFlt-1和PLGF水平.其中,子痫前期高风险因素(A组)122例,正常妊娠(B组)230例.结果 A组血清sFlt-1浓度为(308.5±85.5) ng/L,明显高于B组的(265.3±98.6)ng/L(P＜0.01),血清PLGF浓度为(30.8±9.0) ng/L,与B组的(30.4±11.6) ng/L相仿(P＞0.05).A组sFlt-1/PLGF比值与体重指数呈正相关(r=0.724,P＜0.01)；当sFlt-1/PLGF比值＞11.0时,预测子痫前期的敏感性为84.0％,特异性97.9％;而B组敏感性为59.1％,特异性为97.1％.结论 孕16-20周,血清sFlt-1/PLGF比值在子痫前期高风险因素孕妇预测子痫前期效果优于正常妊娠孕妇.
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